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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CREBBP All Species: 24.24
Human Site: S469 Identified Species: 44.44
UniProt: Q92793 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92793 NP_001073315.1 2442 265351 S469 T G Q Q N A T S L S N P N P I
Chimpanzee Pan troglodytes XP_523285 2442 265358 S469 T G Q Q N A T S L S N P N P I
Rhesus Macaque Macaca mulatta XP_001095225 2442 265320 S469 T G Q Q N A T S L S N P N P I
Dog Lupus familis XP_851777 2404 260682 A448 S S M Q R A Y A A L G L P Y L
Cat Felis silvestris
Mouse Mus musculus P45481 2441 265456 S468 A G Q Q N A T S L S N P N P I
Rat Rattus norvegicus NP_596872 2444 265618 S468 A G Q Q N A T S L S N P N P I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414964 2447 266615 S458 T G Q Q N N P S L S N P N P I
Frog Xenopus laevis NP_001088637 2428 264402 G443 L P V S L A S G V Q N P I G T
Zebra Danio Brachydanio rerio NP_001082924 2111 234059 S370 V E G D M Y E S A N S R D E Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524642 3276 340709 A630 G G A G G G A A G A G G N L Q
Honey Bee Apis mellifera XP_001122031 2606 284119 A574 E M R R A Y D A L G I P C P T
Nematode Worm Caenorhab. elegans P34545 2056 227161 P315 N G Q P I R G P N Q M M M M S
Sea Urchin Strong. purpuratus XP_782558 2635 288594 S671 S M A R A F E S L G I P I K T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 99.4 93.9 N.A. 94.8 95.8 N.A. N.A. 88 76 61.5 N.A. 36.5 42.7 30.5 38.5
Protein Similarity: 100 99.9 99.6 95.5 N.A. 96.4 97.2 N.A. N.A. 92 83.3 68.8 N.A. 46.7 54.7 43.9 50.9
P-Site Identity: 100 100 100 13.3 N.A. 93.3 93.3 N.A. N.A. 86.6 20 6.6 N.A. 13.3 20 13.3 20
P-Site Similarity: 100 100 100 33.3 N.A. 93.3 93.3 N.A. N.A. 86.6 33.3 26.6 N.A. 26.6 40 13.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 16 0 16 54 8 24 16 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 0 8 0 0 8 0 0 0 0 0 8 0 0 % D
% Glu: 8 8 0 0 0 0 16 0 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 62 8 8 8 8 8 8 8 16 16 8 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 16 0 16 0 47 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % K
% Leu: 8 0 0 0 8 0 0 0 62 8 0 8 0 8 8 % L
% Met: 0 16 8 0 8 0 0 0 0 0 8 8 8 8 0 % M
% Asn: 8 0 0 0 47 8 0 0 8 8 54 0 54 0 0 % N
% Pro: 0 8 0 8 0 0 8 8 0 0 0 70 8 54 0 % P
% Gln: 0 0 54 54 0 0 0 0 0 16 0 0 0 0 8 % Q
% Arg: 0 0 8 16 8 8 0 0 0 0 0 8 0 0 0 % R
% Ser: 16 8 0 8 0 0 8 62 0 47 8 0 0 0 8 % S
% Thr: 31 0 0 0 0 0 39 0 0 0 0 0 0 0 24 % T
% Val: 8 0 8 0 0 0 0 0 8 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 16 8 0 0 0 0 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _